Metacaspases are enzymes that induce cell death in plants and fungi, which makes them ideal candidates for antiparasitic and antifungal drugs in humans. The Fox Lab is exploring metacaspases in S. commune. The goal of this project was to synthesize potential metacaspase inhibitors for S. commune which would allow the Fox Lab to continue to explore the enzyme function and deduce the three-dimensional structure of the enzyme-inhibitor complex. Berg (2010) synthesized a metacaspase inhibitor for the organism Trypanosoma brucei, however, his synthesis was not very flexible in terms of changing potential R-groups on the amino-acid and on the benzothiazole ring in the inhibitor, therefore limiting its extension to other organisms like S. commune. Demkiw (2016) discussed a synthetic pathway to generate ketones that allows for changes to R-groups, so we used Demkiw’s synthetic pathway to synthesize potential inhibitors based on Berg’s inhibitor for Trypanosoma brucei. In this presentation I will discuss multiple syntheses of potential S. commune metacaspase inhibitors via Demkiw’s synthetic pathway.