Neuromodulation is a scientific phenomenon widely used in therapeutic treatment as well as treatment of diseases associated with brain malfunction. Associated with the change of neuron firings, neuromodulation allows for alteration and control of nerve activity. Current methods are invasive and deliver low performance on target specificity. Ultrasound (US) is known for its great spatial resolution and ability to move through tissue and bone noninvasively. The goal of this research is to explore the effects of US as a method of neuromodulation on the third nerve of a crayfish as a testbed system.