The global obesity epidemic is accelerating at an alarming rate carrying significant health and economic consequences. Given that obesity is not a single disease, but a collection of disorders that share obesity as a common symptom, a uniform approach cannot be applied for the prevention, diagnosis, or treatment of obesity. Cortisol imbalances, such as hypercortisolism, have been linked to obesity due to its effects on the body that can contribute to weight gain. Cortisol has far-reaching effects across numerous organ systems, thanks to the presence of its receptors in almost every tissue in the body. High cortisol levels are associated with increased eating, the production of visceral fat, and muscle resistance to insulin — all leading to weight gain. Bariatric surgery is the most effective and long-lasting treatment option targeting weight reduction; however, a significant portion of patients experience weight regain following surgery. Interestingly, many post-bariatric surgery patients with normal cortisol levels still experience weight regain leading us to hypothesize that single nucleotide polymorphisms associated with cortisol hypersensitivity are a factor leading to weight regain post-bariatric surgery. Several SNPs that have been studied show an association with heightened cortisol sensitivity. Our current research is investigating the relationship between the allele frequency of certain SNPs (rs41423247, rs1360780, and rs12086634), and weight regain post-bariatric surgery. Through a collaboration with Ellis Hospital Bariatric Care Center, we collected patient DNA and clinical information to track patient weights following bariatric surgery. Our findings indicate no significant correlation between weight regain and SNPs rs414 and rs136. However, a correlation exists between SNP, rs120 and weight regain following bariatric surgery. The ability to predict the risk of weight regain following bariatric surgery is a valuable tool that can be used in the post-operative management of patients, potentially improving their chances of long-term success.